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. 2019 Sep 23;27(9):1079–1088. doi: 10.3727/096504019X15579146061957

Figure 1.

Figure 1

Profilin 2 (PFN2) is highly expressed in head and neck cancer (HNSC) and correlates with poor prognosis. (A) Gene alterations and mRNA dysregulations of the PFN gene family in HNSC. Data were obtained from the cBioPortal online database. (B) Data from the Gene Expression Profiling Interactive Analysis (GEPIA) database showed a significant upregulation of PFN2 mRNA in HNSC tissues when compared with noncancerous tissues. (C) Survival analysis using the GEPIA database showed high PFN2 expression was correlated with shorter overall survival. HR, hazard ratio. (D) The expression of PFN2 in five different HNSC cell lines and control oral epithelial cells were detected by Western blot. (E) Quantitative analysis of the Western blot results in (D). Data were expressed as mean ± SEM from five independent experiments, n = 5. *p < 0.05, **p < 0.01.