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Working model. Shown is a working model depicting how 1,25(OH)2D3 inhibits CRC cell progression. 1,25(OH)2D3 inhibits cancer development through increasing the expression of VDR, which directly bind to the lncTCF7 promoter region. This combination leads to a decreased lncTCF7 level and Wnt depression, thereby repressing CRC cell EMT.
