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Overexpression of CDK4 partially rescued the miR-338-3p-induced biological effects on MM cells. (A) The CDK4 protein expression was detected in MM1S cells cotransfected with either miR-338-3p or miR-NC and with/without CDK4 overexpression vector. (B) Cell proliferation, (C) cell cycle progression, and (D) apoptosis were determined in MM1S cells cotransfected with either miR-338-3p or miR-NC and with/without CDK4 overexpression vector. *p < 0.05; **p < 0.01.
