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. 2019 Mar 29;27(4):449–458. doi: 10.3727/096504017X15016337254623

Figure 2.

Figure 2

miR-125a-5p inhibited the secretion of HBV and not the replication of HBV-DNA. HepG2.2.15 and HepG3X cells were transfected with miR-125a-5p mimic or miR-negative control of mimic (miR-NC) for 48 h. (A) The level of miR-125a-5p in HepG2.2.15 and HepG3X cells was determined by qRT-PCR. (B) The copies of HBV DNA were not significantly reduced in HepG2.2.15 and HepG3X cells transfected with miR-125a-5p mimic compared with cells transfected with miR-NC. Transfection with miR-125a-5p mimic had a significant inhibitory effect on (C) HBsAg and (D) HBeAg levels compared with cells transfected with miR-NC. All data are presented as mean ± SEM, n = 6. ##p < 0.01, ###p < 0.001 versus miR-NC.