Table 5.
Factors Influencing CR Achievement by Logistic Regression Model Analysis
| Parameters | Univariate Logistic Regression | Multivariate Logistic Regression | ||||||
|---|---|---|---|---|---|---|---|---|
| p Value | OR | 95% CI | p Value | OR | 95% CI | |||
| Lower | Higher | Lower | Higher | |||||
| DEB-TACE (vs. cTACE) | <0.001 | 7.255 | 2.485 | 21.179 | 0.002 | 5.858 | 1.949 | 17.606 |
| Age > 61 years | 0.648 | 0.812 | 0.331 | 1.991 | – | – | – | – |
| Male | 0.474 | 1.615 | 0.434 | 6.010 | – | – | – | – |
| Two or more cycles of treatment | 0.649 | 0.760 | 0.233 | 2.476 | – | – | – | – |
| History of HB | 0.413 | 1.727 | 0.466 | 6.400 | – | – | – | – |
| History of cirrhosis | 0.349 | 1.591 | 0.603 | 4.199 | – | – | – | – |
| Previous cTACE treatment | 0.456 | 1.410 | 0.572 | 3.479 | – | – | – | – |
| Previous surgery | 0.200 | 1.900 | 0.712 | 5.069 | – | – | – | – |
| Previous systemic chemotherapy | 0.982 | +∞ | <0.001 | +∞ | – | – | – | – |
| Previous radiofrequency ablation | 0.661 | 0.703 | 0.145 | 3.404 | – | – | – | – |
| Multifocal disease | 0.559 | 0.758 | 0.298 | 1.924 | – | – | – | – |
| Tumor size ≥ 5 cm | 0.205 | 0.552 | 0.220 | 1.383 | – | – | – | – |
| Tumor location-Bilobar | 0.686 | 0.810 | 0.291 | 2.253 | – | – | – | – |
| Venous invasion | 0.017 | 0.158 | 0.035 | 0.714 | 0.108 | 0.271 | 0.055 | 1.333 |
| Higher BCLC stage | 0.124 | 0.629 | 0.348 | 1.135 | – | – | – | – |
| Child–Pugh B stage (vs. A stage) | 0.959 | <0.001 | <0.001 | +∞ | – | – | – | – |
| Higher ECOG performance status | 0.939 | 0.971 | 0.454 | 2.076 | – | – | – | – |
| AFP > 38.55 μg/L | 0.026 | 0.334 | 0.127 | 0.879 | 0.189 | 0.490 | 0.169 | 1.422 |
| CEA > 2.8 μg/L | 0.276 | 0.600 | 0.240 | 1.503 | – | – | – | – |
| CA19-9 > 14.35 ku/L | 0.411 | 0.680 | 0.271 | 1.704 | – | – | – | – |
Data are presented as p value, OR (odds ratio), and 95% CI (confidence interval). Factors affecting CR achievement were determined by univariate logistic regression analysis, while all factors with p ≤ 0.1 were further detected by multivariate logistic regression analysis. A value of p < 0.05 was considered significant. BCLC stage was scored as 1-Stage A, 2-Stage B, 3-Stage C. CR, complete response.