TABLE 2.

Descriptive statistics and results of multivariable analyses of estimated ratios of means of maximal wound area after treatment of a mast cell tumor with TT in 99 dogs in which locoregional LNs were not enlarged that subsequently developed wounds, and in the subset of 39 dogs with cutaneous and SC MCTs on the lower limb

(Potential) determinant and categories	No. dogs	Mean of maximum wound areas (25th, 75th percentiles; cm2)	Adjusted estimated ratio of means a	95% CI	P value b
Tumor location					.92
Body	43	6.3 (1.2, 7.4)	0.8	0.5‐1.4	.48
Upper limb	17	7.2 (1.0, 6.5)	0.8	0.4‐1.5	.43
Lower limb	39	10.9 (1.8, 12.8)	Reference category
Tumor volume at time of first treatment (cm 3 )					<.001
	99	1.6 (0.3, 2.2)	0.2 c	0.0‐1.0	.04
Cytological grade of tumor					.08
Low or low suspected	88	8.4 (1.5, 8.4)	Reference category
High or high suspected	7	5.6 (2.2, 8.8)	0.4	Undefined to 1.1 d
Grade not available	4	10.1 (1.3, 19.0)
Tumor type (lower limb)					.09
Cutaneous	25	10.1 (1.7, 7.5)	Reference category
Subcutaneous	14	12.3 (5.0, 20.1)	0.5 e	0.2‐1.3	.16

Abbreviations: CI, confidence interval; MCT, mast cell tumor; TT, tigilanol tiglate.

^aAdjusted for all other variables in table (ie, all three variables were simultaneously fitted in the same model; n = 95 dogs; tumor volumes were first transformed to tumor volumes⁻²).

^bBolded P values are overall likelihood ratio test P values for the variables; unbolded P values are Wald P values for assessing the respective category relative to the reference category.

^cEstimated ratio of mean wound area for a 1 unit increase in tumor volume⁻².

^dLikelihood‐based confidence interval (rather than Wald confidence intervals as elsewhere); lower limit could not be defined.

^eAdjusting for tumor volume and cytological grade.