TABLE 3.
Geometric mean (95% confidence interval) of plasma equilibrium concentrations of angiotensin peptides (APs) and mean (SD) measures of surrogate markers of plasma renin activity (PRA‐S) and angiotensin converting enzyme (ACE‐S) and ratio of alternative to traditional APs (ALT : TRAD) in 6 cats with cardiomyopathy while receiving no renin‐angiotensin‐aldosterone system inhibiting drugs (no RAASi), while receiving angiotensin receptor blocker (ARB), and after in vitro incubation of plasma with recombinant human angiotensin converting enzyme‐2 (rhACE2)
| No RAASi (A) | ARB (B) | No RAASi + ACE2 (C) | ARB + ACE2 (D) | P value | |
|---|---|---|---|---|---|
| AT1 (pg/mL) | 61 | 276 | 44 | 194 | .003 |
| (19‐202) | (86‐891) | (16‐118) | (56‐678) | A vs B, P = .02 | |
| A vs C, P = .04 | |||||
| C vs D, P = .02 | |||||
| B vs D, P = .01 | |||||
| AT2 (pg/mL) | 199 | 913 | <LLOD a | <LLOD a | <.001 |
| (73‐539) | (282‐2955) | A vs B, P = .003 | |||
| A vs C, P < .001 | |||||
| B vs D, P < .001 | |||||
| Ang1‐9 (pg/mL) | <LLOD b | <LLOD b | 4.6 | 18 | .02 |
| (1.5‐12.1) | (3.3‐99) | C vs D, P = .04 | |||
| B vs D, P = .04 | |||||
| Ang1‐7 (pg/mL) | 30 | 147 | 29 | 159 | .001 |
| (10.4‐87) | (43‐508) | (7.1‐122) | (47‐539) | A vs B, P = .01 | |
| C vs D, P = .01 | |||||
| Ang1‐5 (pg/mL) | 195 | 552 | 283 | 800 | .02 |
| (80‐474) | (148‐2064) | (106‐754) | (253‐2528) | A vs C, P = .004 | |
| AT3 | 10 | 47 | NA | NA | .67 |
| (2.6‐41) | (12‐186) | ||||
| AT4 | 3.7 | 20 | NA | NA | .48 |
| (1.1‐12) | (5.5‐73) | ||||
| PRA‐S | 375 | 1879 | 61 | 321 | <.001 |
| (331) | (1772) | (46) | (303) | A vs B, P = .007 | |
| A vs C, P < .001 | |||||
| C vs D, P = .007 | |||||
| B vs D, P < .001 | |||||
| ACE‐S | 3.4 | 3.3 | 0.034 | 0.009 | <.001 |
| (1.0) | (0.3) | (0.033) | (0.010) | A vs C, P < .001 | |
| B vs D, P < .001 | |||||
| ALT : TRAD | 0.88 | 0.62 | 7.1 | 6.1 | <.001 |
| (0.13) | (0.20) | (1.4) | (2.6) | A vs C, P < .001 | |
| B vs D, P = .005 |
Abbreviations: Ang1‐5, angiotensin 1‐5; Ang1‐7, angiotensin 1‐7; Ang1‐9, angiotensin 1‐9; AT1, angiotensin 1; AT2, angiotensin 2; AT3, angiotensin 3; AT4, angiotensin 4; LLOD, lower limit of detection.
All values less than the lower limit of detection, 2.0 pg/mL.
All values less than the lower limit of detection, 3.5 pg/mL.