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. 2019 Feb 5;27(2):147–155. doi: 10.3727/096504017X15021536183517

Figure 6.

Figure 6

miR-26b mimic restrains tumor growth in vivo. The glioma xenograft mouse model was created by subcutaneous injection of U-373 cells pretreated with or without miR-26b mimic to specific pathogen-free (SPF) nude mice. (A) Representative tumors from the two groups of mice are shown (n = 5). (B) Tumor growth trend in lncRNA COX-2 mice and control group mice is shown. The expression of miR-26b, COX-2 (C), p-ERK1, and p-JNK (D) was detected in the glioma model mice by Northern blot or Western blot. (E) The production of matrix metalloproteinase-2 (MMP-2) and MMP-9 was detected by immunohistochemistry. *p < 0.05, **p < 0.01, ***p < 0.001 versus control group.