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. 2019 Feb 21;27(3):371–377. doi: 10.3727/096504018X15178740729367

Figure 3.

Figure 3

miR-18a-5p targets and inhibits RUNX1. (A) Prediction of the target gene of miR-18a-5p by sequence analysis. (B) The luciferase activity in cells with wt or mut RUNX1 when cotreated with miR-18a-5p mimic or mimic control using luciferase reporter assay. (C) The mRNA level of RUNX1 in A375 cells with miR-18a-5p mimic or mimic control using qRT-PCR. (D) The protein level of RUNX1 in A375 cells with miR-18a-5p mimic and mimic control using Western blotting. (E) The protein level of RUNX1 in MM tissues and normal skin tissues using Western blotting. *p < 0.05 and ***p < 0.001 compared with normal or mimic control.