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. 2019 May 7;27(5):557–564. doi: 10.3727/096504018X15264647024196

Figure 3.

Figure 3

NLRP3 silencing or NF-κB blockage abrogated IL-1β-increased cell proliferation and invasion. U87 cells were pretreated with IL-1β and then transfected with NLRP3-shRNA or treated with PDTC. (A) Cell growth detected by CCK-8 assay. (B) Cell invasion detected by Transwell assay. (C) NF-κB p65 expression detected by Western blot. Control: normal cultured U87 cells; IL-1β + NC: U87 cells treated with IL-1β and transfected with empty vectors; IL-1β + shNLRP3: U87 cells treated with IL-1β and transfected with NLRP3-shRNA; IL-1β + PDTC: U87 cells treated with IL-1β and PDTC. *p < 0.05, **p < 0.01, ***p < 0.001.