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. 2019 Mar 29;27(4):459–467. doi: 10.3727/096504018X15193500663936

Figure 4.

Figure 4

IRS1 knockdown inhibits proliferation and invasion of MCF-7 and MDA-MB-231 cells. (A) MCF-7 and MDA-MB-231 cells were transfected with IRS1 small interfering RNA (siRNA) or NC siRNA. Western blot analysis was conducted to detect IRS1 protein expression. *p < 0.05 compared with NC siRNA. (B) Effect of IRS1 knockdown on MCF-7 and MDA-MB-231 cell proliferation was analyzed by the CCK-8 assay. *p < 0.05 compared with NC siRNA. (C) IRS1 siRNA- or NC siRNA-transfected MCF-7 and MDA-MB-231 cells were subjected to Transwell invasion assay, and the number of invasive cells was counted. *p < 0.05 compared with NC siRNA.