Fig. 1.

A genetically encoded photo-crosslinker identifies cellular interactors of unexplored SEPs. (A) Schematic depicting the strategy used in this work to introduce the photo-crosslinking amino acid AbK (structure within inset circle) into SEP transgenes and identify their protein targets in cells. (B) Heatmap of the relative spectral count enrichment corresponding to protein preys identified from AP-MS experiments with the indicated SEP baits in the presence or absence of UV (mean of three biological replicates).