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. 2021 Jan;159:58–74. doi: 10.1016/j.pbiomolbio.2020.06.007

Fig. 1.

Fig. 1

Human-based biophysical models and biomarkers of electro-mechanical function. A: Schematic representation of ionic currents, calcium dynamics and contractile properties considered. Here the electrophysiology model diagram represents the ToR-ORd model (adapted from Tomek et al., 2019 as allowed by the CC-BY license). B: Biomarkers computed. B1: Typical AP waveform and relative biomarkers (tp: time to AP peak; APD50/APD90: AP duration at 50/90% repolarisation). Inset: AP repolarisation abnormalities (early afterdepolarisations, EADs). B2: Typical CaT waveform and relative biomarkers (tp: time to CaT peak; rt50/rt90: time to 50/90% decay from CaT peak). B3: Typical active tension waveform and relative biomarkers (tp: time to active tension peak; rt50/rt95: time to 50/95% decay from active tension peak). Inset: Active tension abnormalities (aftercontractions, ACs).