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Electro-mechanical coupling and repolarisation. Electro-mechanical coupling (EM) mitigates the APD prolongation induced by Dofetilide, and delays EADs onset (A-B). This is mediated by a faster CaT decay under EM coupling (C), which recovers almost entirely during AP repolarisation. Results obtained with the ToR-ORd+Land model. CL: cycle length.
