Fig. 7.

Verapamil. A: Experimental evidence of Verapamil-induced effects on cell shortening (figures reproduced from Nguyen et al. (2017) as allowed by the CC-BY licence). B: Single cell and tissue simulation of Verapamil effects. B1: Dose-response curves of peak active tension for Verapamil, using the ToR-ORd+Land and ORd+Land models. B2: Longitudinal displacement of the free face computed in tissue slabs exposed to different drug concentrations. Inset: superimposed tissue slabs at maximal shortenings (undeformed tissue configuration in grey). C: In-vitro (C1) and in-silico (C2-C3) experiments of Verapamil-induced effects on electrophysiology. C1: Human trabeculae (figure reproduced with permission from Page et al., 2016). C2: Verapamil-induced effects on AP and CaT for ToR-ORd+Land and ORd+Land models. C3: APD90 prolongation under Verapamil exposure with respect to control APD90 for both models.