Fig. 8.

Quinidine. A: Experimental evidence on Quinidine-induced effects on human AP (A1, figure reproduced with permission from Page et al., 2016) and cell shortening (A2, figure reproduced from Nguyen et al. (2017) as allowed by the CC-BY licence). B: Single cell simulations of Quinidine effects. B1: Comparison between the ToR-ORd+Land and ORd+Land models in response to Quinidine action in terms of AP and CaT. B2: Quinidine dose-response curves for active tension reduction for both the ToR-ORd+Land and ORd+Land models.