Table 2.
Impact of the histological subtype, location, grade, tumor size, PDGFA and D expression levels on MFS in multivariate analysis in the non-GIST sarcoma cohort and impact of the AFIP score, PDGFA and D expression levels on MFS in multivariate analysis in the GIST cohort
| Non-GIST cohort |
GIST cohort |
|||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Histological subtype | N/A | >0.07 | N/A | N/A |
| Location | N/A | >0.4 | N/A | N/A |
| Grade | HR 0.8 (0.44-1.52) | 0.5 | N/A | N/A |
| Tumor size | HR 5.37 (2.07-19.69) | 1.3 × 10−4 | N/A | N/A |
| AFIP score | N/A | N/A | HR 26.38 (3.5 to >100) | 9.3 × 10−5 |
| PDGFA | HR 1.27 (1.01-1.6) | 4.3 × 10−2 | HR 0.98 (0.73-1.38) | 0.9 |
| PDGFD | HR 0.8 (0.69-0.94) | 4.99 × 10−3 | HR 0.75 (0.56-0.98) | 3.7 × 10−2 |
AFIP, American Forces Institute of Pathology; GIST, gastrointestinal stromal tumor; HR, hazard ratio; MFS, metastasis-free survival; PDGF, platelet-derived growth factor.