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. 2021 Jan 22;118(4):e2022120118. doi: 10.1073/pnas.2022120118

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Fig. 3. — Focused sublibrary screens in cells deficient in known stress and amino acid sensing pathways. (A–C) Comparisons of CRISPR scores (CSs) from focused sublibrary screens in wild-type HEK293T to those in cells lacking GCN2, ATF4, or NPRL3. The top 25 differential CSs for each screening pair are included in an adjacent bar graph. The tRNA synthetase genes targeted in the library are highlighted in purple. Genes encoding GATOR2 components are highlighted in light blue. (D) Scores for tRNA synthetase genes present in the focused sublibrary in screens across all indicated cell lines. (E) Focused screens performed at 8 versus 16 d after transduction, highlighting genes whose scores are time dependent.