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Overall structure of human SARM1. (A) Domain arrangement of SARM1 and the octameric model fitted into the composite EM map combining the C8 symmetry map and the TIR-focused refined C1 map. The dimensions of the octamer are indicated. (B) Ribbon diagram of the octameric model, color coded by domains. ARM: light pink; SAM: sky blue; TIR: wheat. (C) Five intramolecular and intermolecular interfaces between SARM1 domains are shown on two extracted protomers.
