Fig. 1.

(a) The diagrammatic sketch of the synthesis of HPBzyme. (b) Schematic diagram of the mechanism by which HPBzyme protects chondrocytes and delays arthritis. HPBzyme remodels the microenvironment of OA through attenuating proinflammatory cytokine/mechanical injury-induced inflammation, reducing extracellular matrix catabolism, and preventing chondrocyte apoptosis via inhibiting the ROS and Rac1-NF-κB signaling. HPBzyme provides a good environment for the recovery of OA via remodeling the OA microenvironment, showing therapeutic potential for OA.