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. 2021 Jan 21;118(4):e2016806118. doi: 10.1073/pnas.2016806118

Fig. 5.

Fig. 5.

Defining the mechanism of action of Bclaf3 and Prkra KO on gastric organoid renewal/renewal. (A) Schematic of the RNA-seq experiment and results of PCA analysis and (B) hierarchical cluster analysis. (C) A Venn diagram summarizing the number of up-regulated genes in each KO clone. (D) An up-regulated gene list for each KO clone. Listed genes are selectively enriched on Lgr5+ stem cells (4). (E) Expression level of interleukins in each KO clone. *P < 0.05 compared to Mock. (F) Expression level of Reg genes induced by administration of interleukins. IL-22 is a positive control (42). *P < 0.05 compared to Mock.