Table 3.
Multiple regression analysis of clinical features associated with LPAC diagnosis.
| Clinical features | FDR LogWorth (95% CI) |
||
|---|---|---|---|
| All cases (n = 308) | Cases with typical imaging features (n = 272) | Cases with typical imaging features and ABCB4 variant (n = 106) | |
| Imaging evidence of intrahepatic micro- or macrolithiasis | 53.8 (52.1–55.5) | — | — |
| Recurrence of symptoms after cholecystectomy | 15.3 (14.8–15.8) | 28.0 (27.1–28.8) | 13.7 (13.0–14.3) |
| Age at first symptoms before 40 yo | 4.8 (4.4–5.1) | 15.5 (14.8–16.2) | 10.9 (10.4–11.4) |
| Clinical and/or imaging evidence of CBD lithiasis | 6.3 (5.9–6.7) | 2.5 (2.2–2.8) | 2.4 (2.1–2.7) |
| No history of obesity or overweight | 2.0 (1.8–2.2) | 6.8 (6.4–7.2) | 6.0 (5.6–6.4) |
| No history of acute cholecystitis | NS | 6.0 (5.7–6.4) | 3.3 (3.0–3.6) |
The FDR LogWorth is a quantitative measure of how strong the association is between diagnosis and clinical features in multiple logistic regression analysis. It is defined as –log10(FDR p value for the likelihood ratio Chi-square test). A value that exceeds 2 is significant at the 0.01 level. ABCB4, ATP-binding cassette subfamily B member 4; CBD, common bile duct; FDR, false discovery rate; LPAC, low-phospholipid-associated cholelithiasis; NS, not significant at the 0.05 level.