Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic mechanism of the miR-351-5p/Miro2 axis in adult neurogenesis
By an unknown mechanism, abnormal stimuli increase the amount of miR-351-5p, which sequentially downregulates Miro2 in HCN cells. Aberrant low Miro2 levels readily induced mitochondrial fission, resulting in excessive mitophagy and cell death in the HCN population, which can contribute to the pathological condition in AD.
