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Seed-based amygdala – vmPFC resting state analysis revealed a significant group difference in the subgenual ACC (sgACC; x = 38). As seen in the bar graph, PI youth exhibited significantly stronger positive connectivity between amygdala and sgACC than NA youth. PI youth had greater positive connectivity than the NA comparison group. Region survived a voxelwise significance threshold of p < 0.005 and region of interest permutation tests p < 0.05 after 5,000 permutations.
