Table 3.

Summary of case reports found in the literature with transitional cell carcinoma recurrence within an intestinal urinary diversion (TCCUD) after radical cystectomy

Author	Journal	Age/sex	Histology at cystectomy	Urinary diversion	Recurrence site	Symptoms at presentation	Months after cystectomy	Upper Tract TCC	Treatment of the recurrence	Additional therapy	Final pathology of TCCUD	Death	Follow-up (months)
Soloway et al. [7]	J Urol. 1972	71/F	N/A	IC	UIA	GE and PC	19	Yes	RT	N/A	TCC	Yes	24
Soloway et al. [7]	J Urol. 1972	57/M	N/A	IC	UIA	PC	13	Yes	PR and formation of a new conduit + NUT	N/A	TCC	Yes	15
Grabstald [8]	J Urol. 1974	58/M	pT3N0	IC	Around the ileal stoma	Tumor formation around the ilea! stoma	48	No	PR	No	TCC infiltrating grade 2 carcinoma with deep invasion into the muscularis of the ileal conduit.	No	18
Wajsman et al. [9]	Urology. 1975	57/M	N/A	IC	UD	GE	108	Yes	PR	CHT	TCC grade II	No	12
Banigo et al. [10]	J Urol. 1975	69/M	N/A	IC	UIA	N/A	36	Yes	PR + Resection of distal left ureter	N/A	TCC	No	9
Allan DM et al. [11]	Br J Urol. 1976	56/M	N/A	IC	UIA	abscess	15	Yes	TR + NUT	None performed	TCC	N/A	N/A
Rubin et al. [12]	Urol Radiol. 1979	68/F	N/A	IC	UD	GE and PC	78	No	PR and reanastomosis of ileal conduit	None performed	TCC	Yes	1 day post surgery
Curran et al. [13]	Postgrad Med J. 1986	66/F	T1G2	IC	UD	GE	48	Yes	PR + NUT	None performed	TCC noninvasive grade I and II	N/A	N/A
Moskovitz et al. [14]	Urol Int. 1986	52/M	N/A	IC	UIA	N/A	15	Yes	NUT+ resection of the ureter with the cuff of ileum. Reanastomosis of the loop.	None performed	TCC	N/A	N/A
Roberts et al. [15]	J Urol. 1987	69/F	T3bNoMx	IC	UD	UTI and upper tract obstruction	4	No	PR + distal portion of the conduit was fashioned into a new stoma	CHT	TCC poorly differentiated transitional	Yes	4
Rosvanis et al. [16]	Cancer. 1989	73/M	CIS	IC	UD	GE	60	Yes	NUT + PR	None performed	TCC noninvasive grade 2	Yes	12
Mulholland et al. [17]	BrJ Urol. 1993	54/M	N/A	IC	UD	GE	N/A	Yes	PR + Resection of 3 cm of ureter	None performed	Grade II TCC without a direct invasion of the submucosa N0M0	N/A	N/A
Garcia et al. [18]	Br J Urol 1993	77/M	pT2G3L1	IC	UD	GE	36	No	Not performed	CHT	TCC	N/A	N/A
Corral et al. [19]	J Urol. 1993	54/M	pT3aNo	IC	UD	GE	12	No	PR	Preoperative and postoperative CHT	Poorly differentiated TCC with transmural extension into serosal adipose tissue with marked angiolymphatic invasion.	No	54
Carter et al. [20]	Eur Urol. 1996	67/M	PT3. No Mo G2	IC	UD	GE, UTI, PC	24	No	TR + new conduit fashioned away from the original stoma	CHT	TCC invading the full thickness of the bowel wall to the surrounding retroperitoneal	Yes	N/A
Inobe T et al. [21]	Int J Urol. 1999	66/M	pT3bG3pN0	IC	UD	No symptoms	4	No	Not performed	Palliative RT	TCC	Yes	7
Sanchez Zalabardo et al. [22]	Actas Urol Esp. 2001	57/M	pT3aN0M0G3	OIN	UD	N/A	108	Yes	PR	CHT and RT	TCC	No	3
Shioji et al. [23]	Urol Nephrol. 2001	67/M	pT3bN2M0	IC	UIA + UD	GE	11	Yes	PR + resection of the ureteroileal junction	None performed	TCCG2	Yes	19
Hara et al.[24]	Urology. 2003	67/M	Invasive bladder cancer	SCN	UIA + UD	N/A	96	Yes	TR +NUT	None performed	TCC, grade 3 + CIS	N/A	N/A
Herawi et al. [25]	Urology. 2006	60/M	N/A	OIN	UD	PC	3	Yes	Biopsies of the ileocolonic neobladder	None performed	TCC noninvasive low- grade	N/A	N/A
Ide et al. [26]	Urology. 2007	73/M	Grade 3, Stage pT1	OIN	UIA	PC	144	Yes	TR+ NUT+ conversion to ileal conduit + urethrectomy	None performed	TCC pT2, grade 3. CIS,	No	6
Moore et al. [27]	Urology. 2007	62/M	pT3N0M0	OIN	UD	GE	12	No	TR+ conversion to ileal conduit + urethrectomy + mesenteric lymphadenectomy.	CHT	TCC high-grade. Positive metastatic lymph nodes	Yes (multiple metastasis liver, lung, and adrenal gland)	15
Kotb et al.[28]	Ecancermedicalscience. 2012	59/F	pT2N0, with squamoid differentation	OIN	UD	GE	156	No	TR+ continent reservoir Urethrectomy	None performed	TCC pT3	No	3
Hadzi-Djokic et al. [29]	Vojnosanit Pregl. 2013	65/M	pT2G2N0M0	OIN	UIA	GE	144	Yes	PR + NUT	None performed	TCC pT2bG2	Yes, for laryngeal carcinoma	12
Yamashita et al. [30]	Int J Urol. 2014	74 /M	pT3aN0M0 + CIS	OIN	UD	GE and PC	72	Yes	Endoscopic resection	BCG instillation for 8 months	TCC pTa + CIS	N/A	N/A
Cakmak et al. [31]	Case Rep Urol. 2014	51/M	grade 3, stage pT1N0M0	OIN	UD	GE	132	No	Endoscopic resection	None performed	TCC low-grade	Yes	18
Kawamoto et al. [32]	Urology Case Reports. 2016	61/M	cT2 pTIS,G3N0	OIN	UIA	PC	108	Yes	TR+ conversion to ileal conduit + NUT	CHT	TCC pT2b, grade 3	No	20
Cherbanyk et al. [33]	Case Rep Urol. 2016	66/M	pT3a pN1 (1/13) cM0, G3, L1	OIN	UD	GE	108	No	Endoscopic resection	CHT	TCC tumor invaded the muscularis propria of the ileal neobladder	N/A	Recurrence in few months in right frontal cerebral mass
Groen, et al. [34]	BMJ Case Rep, 2017	65/M	cT4aN2M1 (pT0N0Mx after neoadjuvant chemotherapy)	OIN	UIA	N/A	108	No	TR+ conversion to ileal conduit	CHT and retroperitoneal lymph one year after urinary diversion	TCC pT2b, N1, grade 3	No	24
Doshi et al. [35]	Case Rep Urol. 2019	71/M	pT3aN0 + CIS	OIN	UD	PC	132	No	TR+ conversion to ileal conduit	CHT (after cystectomy)	TCC HG extending into the surrounding fat	N/A	N/A

OIN – orthotopic ileal neobladder; SCN – sigmoid colon neobladder; IC – Ileal Conduit; GE – gross hematuria; PC – positive urine cytology; UTI – urinary tract infection; N/A – not available; UIA – ureteroileal anastomosis; UD – recurrence with the urinary diversion, away from both ureteroileal anastomoses; CHT – chemotherapy, RT – radiation therapy; NUT– nephroureterectomy; TR – total resection of the neobladder (with the mesentery); PR – partial resection; HG – high-grade; TCC – transitional cell carcinoma