Fig. 2.

VPC Visual predictive check (n=1000) of vancomycin plasma (left) and cerebrospinal fluid (right) concentration versus time after dose; grey points are observations, black lines are the 2.5th, 50th and 97.5th percentiles of the observed data, and the shaded area is a non-parametric 95% confidence interval for the corresponding simulated concentrations. Red asterisks represent where the observed percentile falls outside the 95% confidence interval for the corresponding simulated concentrations.