Table 3.

Parameter estimates with uncertainty from the final model.

Parameter	Estimate (%RSE)	IIV % CV (%RSE)	Bootstrap median (95% CI)	Bootstrap IIV % CV (95%CI)
CL (L/h/70 kg)	9.29(5.2)	26(51.4)	9.5 (8.7 – 10.9)	25 (13 - 36)
V (L/70 kg)	54.4(11.5)	0 FIX	53.5 (47.6 – 119.8)	0 FIX
CLCSF (L/h)	0.002(12.9)	29(35.6)	0.002 (0.002 - 0.003)	27 (11 - 36)
VCSF (L)	0.109(23.8)	60(58)	0.11 (0.069 - 0.172)	59 (17 - 87)
sigmaprop plasma (% CV)	31.31(0.6)	-	30.1 (15.1 – 45.0)	-
sigmaprop CSF (% CV)	45.8(0.3)	-	44.8 (28.1 – 55.2)	-

Note: CL is clearance, V is volume of distribution, CSF is cerebrospinal fluid, CV is coefficient of variation $\left(100x\sqrt{\Omega }\right)$, IIV is inter individual variability, RSE is relative standard error $\left(\frac{\mathit{standard}\mathit{error}\mathit{of}\mathit{estimates}}{\mathit{final}\mathit{estimates}}\right)$, non-parametric bootstrap was derived from 1000 samples.