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. 2020 Aug 27;2(3):zcaa019. doi: 10.1093/narcan/zcaa019

Graphical Abstract.

Graphical Abstract

Activation-induced deaminase (AID) and uracil N-glycosylase (UNG) have several different functions and effects in normal and cancer B cells, with UNG protecting cell fitness from AID in both contexts and the net outcome being context dependent.