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STAT3 secondary structure. STAT3 protein structure includes N‐terminal domain, coiled coil and DNA binding domains, a linker domain, SH2 domain involved with dimer formation and the C‐terminus. The C‐terminus of the (A) STAT3α isoform and (B) STAT3β isoform confers distinct functions of the two isoforms. STAT3, signal transducer and activator of transcription 3
