TABLE 1.

Identified lncRNAs in TNBC

lncRNAs	Expression	Biological function	Potential Targets	References
GAS5	Down	Inhibit cell proliferation and invasion; Promote cell apoptosis; Inhibit paclitaxel, cisplatin, adriamycin and PI3K/mTOR inhibitor resistance	miR‐378a‐5p/SUFU, miR‐196a‐5p	47, 48, 49, 108
LINC02095	Up	Promote cell proliferation	SOX9	55
HOTAIR	Up	Promote cell migration and invasion; imatinib and lapatinib resistance	miR‐148a; LEF1/TCF4	92, 93, 109
WT1‐AS	Down	Inhibit cell migration and invasion	TGF‐β1	96
LINC00096	Up	Promote cell proliferation and invasion	miR‐383‐5p/RBM3	50
DRHC	Down	Inhibit cell proliferation	HOTAIR	60
HEIH	Up	Promote cell proliferation Inhibit cell apoptosis	miR‐4458/SOCS1	51
LUCAT1	Up	Promote cell proliferation, cell cycle progression and metastasis; Inhibit cell apoptosis	miR‐5702	64
CCAT1	Up	Promote cell proliferation, migration, and invasion	miR‐218/ZFX	77
ASRPS	Down	Inhibit angiogenesis	STAT3	125
HAND2‐AS1	Down	Inhibit cell proliferation	RUNX2	65
LINC01133	Up	Promote cell stem cell (CSC)‐like phenotypic traits	KLF4	119
LINC01096	Up	Promote cell proliferation, migration, and invasion; Inhibit cell apoptosis	miR‐3130‐3p	97
PAPAS	Up	Promote cell migration and invasion	miR‐34a	83
HCP5	Up	Promote cell proliferation; Inhibit cell apoptosis	miR‐219a‐5p/BIRC3	52
NRAD1	Up	Promote cell proliferation and CSC‐like phenotypic traits	‐	122
LINK‐A	Up	Promote immunotherapy resistance; AKT inhibitors resistance; glycolysis reprogramming	PI3K/GPCR; Akt; HIF1α	18, 110, 127
MIR503HG	Down	Inhibit cell migration and invasion	miR‐103/OLFM4	78
AWPPH	Up	Promote cell proliferation; Promote carboplatin resistance	miR‐21; FZD7	63, 112
PTCSC3	Down	Inhibit cell proliferation	H19	61
NRON	Down	Inhibit cell proliferation	snaR	62
sONE	Down	Inhibit cell proliferation, migration, and invasion	miR‐34a/15a/16, let‐7a, TP53/c‐Myc; NOS3	84, 85
NAMPT‐AS	Up	Promote cell metastasis	miR‐548b‐3p/ NAMPT	79
DANCR	Up	Promote cell proliferation and invasion, and CSC‐like phenotypic traits	miR‐216a‐5p; RXRA; EZH2, CD44, ABCG2; Nanog, SOX2, and OCT4	56, 98, 120
NEAT1	Up	Inhibit cell apoptosis; Promote cell cycle progression; Promote cisplatin and paclitaxel resistance and cancer stemness	‐	75
TROJAN	Up	Promote cell proliferation and invasion	ZMYND8	17
POU3F3	Up	Promote cell proliferation; Inhibit cell apoptosis	Caspase‐9	66
NEF	Down	Inhibit cell migration and invasion	miR‐155	99
ZEB2‐AS1	Up	Promote cell proliferation, metastasis and EMT	ZEB2	88
LncKLHDC7B	Down	Inhibit cell migration and invasion; Promote cell apoptosis	KLHDC7B	100
HIF1A‐AS2	Up	Promote cell migration and invasion	‐	101
LINC00339	Up	Promote cell proliferation; Inhibit cell cycle arrest, apoptosis	miR‐377‐3p/HOXC6	53
LINC00152	Up	Promote cell proliferation and invasion; Inhibit cell apoptosis	PTEN, BRCA1	57, 58
AFAP1‐AS1	Up	Promote EMT	Wnt/β‐catenin	81
PDCD4‐AS1	Down	Inhibit cell proliferation and migration	PDCD4	59
HOST2	Down	Inhibit cell proliferation	let‐7b/CDK6	54
BORG	Up	Promote doxorubicin resistance	RPA1	115
PVT1	Up	Promote cell proliferation and migration, EMT	p21, KLF5/β‐catenin	89, 90
H19	Up	Promote paclitaxel resistance and CSC‐like phenotypic traits	Akt	114, 123
TP73‐AS1	Up	Promote cell vasculogenic mimicry	miR‐490‐3p/TWIST1	126
TUG1	Down	Enhance cisplatin sensitivity	miR‐197/NLK	113
MIR100HG	Up	Promote cell proliferation, Inhibit cell cycle arrest	p27	72
LINC01638	Up	Promote cell proliferation, metastasis and CSC‐like phenotypic traits	c‐Myc	121
ARNILA	Down	Promote EMT, invasion and metastasis	miR‐204/SOX4	91
LINC‐ZNF469‐3	Up	Promote cell invasion, stemness properties and lung metastasis	miR‐574‐5p/ZEB1	87
ROR	Up	Promote cell invasion and metastasis	miR‐145/MUC1; miR‐145/ARF6	102, 103
AIRN	Down	Inhibit cell migration and invasion	Wnt/β‐catenin/mTOR/PI3K	104
MANCR	Up	Promote cell proliferation, Inhibit DNA damage	‐	128
RMST	Down	Inhibit cell proliferation, invasion and migration; Promote cell apoptosis, and regulate cell cycle.	‐	76
SKAI1BC	Up	Promote cell migration and invasion	KAI1	105
ANRIL	Up	Promote cell proliferation, Inhibit cell apoptosis	miR‐199a	67
MALAT1	Up	Promote cell proliferation, cell cycle arrest, and invasion; Inhibit cell apoptosis	miR‐129‐5p; miR‐1/Slug; miR‐448/KDM5B	68, 106, 149
SNHG12	Up	Promote cell proliferation and migration, Inhibit cell apoptosis	MMP13	94
HULC	Up	Promote cell metastasis	MMP‐2, MMP‐9	107
SNAR	Up	Promote cell proliferation, migration and invasion	‐	95
LINP1	Up	Promote DNA DSB repair, and radiotherapy resistance	Ku80	117
PCAT6	Up	radiotherapy resistance	miR‐185‐5p/TPD52	118