TABLE 2.

Population pharmacokinetic estimates for the final model and bootstrap results^e

Parameter	Base model estimate (RSE%)	Final model estimate (RSE%)	Median bootstrap value of the final model (95% CI)
Population parameters
CL (liters/kg/h)a
θCL	0.46 (32.01)	0.45 (12.63)	0.45 (0.36–0.52)
θeGFR		0.19 (20.60)	0.20 (0.11–0.27)
θSIRS		0.35 (40.70)	0.36 (0.10–0.63)
Vc (liters/kg)b
θV	0.49 (34.59)	0.49 (24.22)	0.48 (0.32–0.70)
θCRRT		0.66 (20.58)	0.67 (0.57–0.98)
Vp (liters/kg)c
θV2	0.34 (24.22)	0.34 (23.60)	0.33 (0.21–0.50)
Q (liters/kg/h)d
θQ	0.29 (33.98)	0.28 (34.90)	0.28 (0.09–0.47)
Between-subject variability
% ωCL	48.54 (20.51)	27.10 (19.01)	26.28 (17.09–36.81)
% ωVc	56.42 (20.13)	31.50 (14.30)	30.47 (20.04–40.17)
Residual variability
Proportional (%)	59.72 (12.15)	33.23 (4.28)	0.33 (0.31–0.35)

^aCL (liters per kilogram per hour) = θ_CL × (eGFR [milliliters per minute]/38.2)^θeGFR × (1 + θ_SIRS)^SIRS × BW × exp(η_CL).

^bV_c (liters per kilogram) = θ_V × (1 + θ_CRRT)^CRRT × BW × exp(η_CL).

^cV_p (liters per kilogram) = θ_V2 × BW.

^dQ (liters per kilogram per hour) = θ_Q × BW.

^eRSE%, percent relative standard error; CL, total body clearance; eGFR, estimated glomerular filtration rate; SIRS, systemic inflammatory response syndrome (0 or 1); V_c, central volume of distribution; CRRT, receiving continuous renal replacement therapy (0 or 1); V_p, peripheral volume of distribution; Q, intercompartmental CL; ω, between-subject variability; BW, body weight.