TABLE 2.
Population pharmacokinetic estimates for the final model and bootstrap resultse
| Parameter | Base model estimate (RSE%) | Final model estimate (RSE%) | Median bootstrap value of the final model (95% CI) |
|---|---|---|---|
| Population parameters | |||
| CL (liters/kg/h)a | |||
| θCL | 0.46 (32.01) | 0.45 (12.63) | 0.45 (0.36–0.52) |
| θeGFR | 0.19 (20.60) | 0.20 (0.11–0.27) | |
| θSIRS | 0.35 (40.70) | 0.36 (0.10–0.63) | |
| Vc (liters/kg)b | |||
| θV | 0.49 (34.59) | 0.49 (24.22) | 0.48 (0.32–0.70) |
| θCRRT | 0.66 (20.58) | 0.67 (0.57–0.98) | |
| Vp (liters/kg)c | |||
| θV2 | 0.34 (24.22) | 0.34 (23.60) | 0.33 (0.21–0.50) |
| Q (liters/kg/h)d | |||
| θQ | 0.29 (33.98) | 0.28 (34.90) | 0.28 (0.09–0.47) |
| Between-subject variability | |||
| % ωCL | 48.54 (20.51) | 27.10 (19.01) | 26.28 (17.09–36.81) |
| % ωVc | 56.42 (20.13) | 31.50 (14.30) | 30.47 (20.04–40.17) |
| Residual variability | |||
| Proportional (%) | 59.72 (12.15) | 33.23 (4.28) | 0.33 (0.31–0.35) |
a
CL (liters per kilogram per hour) = θCL × (eGFR [milliliters per minute]/38.2)θeGFR × (1 + θSIRS)SIRS × BW × exp(ηCL).
b
Vc (liters per kilogram) = θV × (1 + θCRRT)CRRT × BW × exp(ηCL).
c
Vp (liters per kilogram) = θV2 × BW.
d
Q (liters per kilogram per hour) = θQ × BW.
e
RSE%, percent relative standard error; CL, total body clearance; eGFR, estimated glomerular filtration rate; SIRS, systemic inflammatory response syndrome (0 or 1); Vc, central volume of distribution; CRRT, receiving continuous renal replacement therapy (0 or 1); Vp, peripheral volume of distribution; Q, intercompartmental CL; ω, between-subject variability; BW, body weight.