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New antifungal drugs and targets. Acylhydrazones impair the production of glucosylceramide. T-2307 and ilicicolin H act by inhibiting the mitochondrial respiratory chain complexes. AR-12, olorofilm, and mohangamides target metabolism-related enzymes. Tacrolimus and cyclosporine inhibit the fungal calcineurin (Crz1) pathway. ACS, acetyl-CoA synthetase.
