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Effects of RDV on mitochondrial respiration (spare respiratory capacity) (● blue, solid lines), ATP levels (■ red, solid lines), and total DNA (♦ green, solid lines) after a 3-day treatment in PC-3, HepG2, PHH, and RPTEC cells. The spare respiratory capacity was normalized by cell numbers. Overall, RDV showed simultaneous inhibition of mitochondrial respiration, ATP levels, and total DNA except in PC-3 cells, where a mitochondria-specific inhibition was observed.
