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In vitro effect of RDV and GS-441524 on mitochondrial proteosynthesis after 5-day treatment in PC-3
| Compound | Mitochondrial and cellular protein synthesis 5-day CC50 (μM)a |
||
|---|---|---|---|
| COX-1 | SDH-A | Cellular ATP | |
| RDV | 8.9 ± 1.1 | 8.6 ± 1.3 | 11.3 ± 3.3 |
| GS-441524 | >100 | >100 | >100 |
| Chloramphenicolb | 2.6 ± 0.6 | >25 | 14.1 ± 3.6 |
CC50 values represent the average ± SD of three or more independent experiments.
Positive control.
