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Inhibition of host DNA and RNA polymerases by the active triphosphate metabolite GS-443902
| Compound | IC50 (μM)a |
||||
|---|---|---|---|---|---|
| DNA pol α | DNA pol β | DNA pol γ | RNA pol II | POLRMT pol | |
| GS-443902 | >200 | >200 | >200 | >200 | >200 |
| Positive Control | Aphidicolin 4.7 ± 3.3 | 3′dTTP 1.9 ± 0.8 | 3′dTTP 1.2 ± 0.6 | α-amanitin 0.0035 ± 0.0015 | 3′deoxy GTP 4.2 ± 1.4 |
IC50 values represent the average ± SD from three independent experiments.
