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Target-based assay activity of (+)-betulin in MDA-MB-231 breast cancer cells.
| Compound | SRBa | NF-κBb | MTPc |
|---|---|---|---|
| (+)-Betulin | 9.5 | 3.9 | 6.5 |
| Paclitaxeld | 0.3 | ||
| Rocaglamided | 0.2 | ||
| Staurosporined | 0.5 |
IC50 value (μM) in MDA-MB-231breast cancer cells. SRB assay=sulforhodamine B assay
IC50 value (μM) for inhibition of nuclear factor kappa B (NF-κB p65).
EC50 value (μM) for loss of mitochondrial transmembrane potential (MTP).
Positive controls.
