Figure 1:

Schematic of Wound Formation and Healing. (A) Wound-healing phases: hemostasis (blood clotting), inflammation, proliferation (tissue growth), and maturation (tissue remodeling). (B) Large wound defect invaded by microbial contamination that implies the need for an appropriate antibiotic-loaded wound dressing. Inflammatory cells migrate to the site of injury by increasing the permeability of the capillaries. By increasing blood flow, important factors and cells cross from the intravascular space into the extra vascular space. Macrophages and neutrophils are also shown that have a crucial role in removing pathogens at the defect site. Abbreviation: PDGF, platelet-derived growth factor. The reproduced with permission from [13].