Table 1.
Summary of the included GDT studies
| First author | Year | Surgery | Pt. Enrolled n |
Pt. Analyzed n (%) |
GDT n (%) |
Controls n (%) |
ASA I n (%) | ASA II n (%) | ASA III-IV n (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GDT | Controls | GDT | Controls | GDT | Controls | |||||||
| Conway [41] | 2002 | Abdominal surgery | 57 | 57 (100) | 29 (50.9) | 28 (49.1) | NA | NA | NA | NA | NA | NA |
| Wakeling [42] | 2005 | Abdominal surgery | 178 | 128 (71.9) | 64 (50) | 64 (50) | NA | NA | NA | NA | NA | NA |
| Pearse [30] | 2005 | Mixed | 160 | 122 (76.3) | 62 (50.8) | 60 (49.2) | NA | NA | NA | NA | NA | 60 (100) |
| Lobo [26] | 2006 | Mixed | 72 | 50 (69.4) | 25 (50) | 25 (50) | NA | NA | NA | NA | NA | NA |
| Donati [31] | 2007 | Mixed | 324 | 135 (41.7) | 68 (50.4) | 67 (49.6) | 0 (0.0) | 0 (0.0) | 9 (13.3) | 11 (16.4) | 59 (86.8) | 56 (83.6) |
| Benes [25] | 2010 | Mixed | 215 | 105 (48.8) | 51 (48.6) | 54 (51.4) | 0 (0.0) | 0 (0.0) | 14 (23.3) | 11 (18.3) | 46 (76.4) | 49 (81.7) |
| Mayer [43] | 2010 | Abdominal surgery | 102 | 60 (58.8) | 30 (50) | 30 (50) | NA | NA | NA | NA | 30 (100) | 30 (100) |
| Brandstrup [32] | 2012 | Abdominal surgery | 185 | 150 (81.1) | 71 (47.3) | 79 (52.7) | 26 (37) | 20 (25) | 37 (52) | 43 (54) | 8 (11) | 16 (20) |
| Salzwedel [27] | 2013 | Mixed | 180 | 160 (88.9) | 79 (49.4) | 81 (50.6) | NA | NA | NA | NA | 33 (41.3) | 33 (40.7) |
| McKenny [44] | 2013 | Gynecological surgery | 113 | 101 (89.4) | 51 (50.5) | 50 (49.5) | NA | NA | NA | NA | NA | NA |
| Scheeren [28] | 2013 | Mixed | 64 | 52 (81.3) | 26 (50) | 26 (50) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 26 (100) | 26 (100) |
| Srinivasa [45] | 2013 | Abdominal surgery | 98 | 74 (75.5) | 37 (50) | 37 (50) | 5 (13) | 5 (13.5) | 20 (54) | 15 (40.5) | 12 (32) | 17 (46) |
| Pearse [19] | 2014 | Mixed | 1735 | 734 (42.3) | 368 (50.1) | 366 (49.9) | 21 (5.7) | 24 (6.6) | 201 (54.5) | 176 (48.1) | 146 (39.8) | 166 (45.3) |
| Phan [46] | 2014 | Abdominal surgery | 131 | 100 (76.3) | 50 (50) | 50 (50) | NA | NA | NA | NA | NA | NA |
| Ackland [47] | 2015 | Mixed | 204 | 187 (91.7) | 95 (50.8) | 92 (49.2) | NA | NA | NA | NA | NA | NA |
| Correa-Gallego [48] | 2015 | Abdominal surgery | 468 | 135 (28.8) | 69 (51.1) | 66 (48.9) | NA | NA | NA | NA | NA | NA |
| Weinberg [34] | 2017 | Abdominal surgery | 68 | 52 (76.5) | 26 (50) | 26 (50) | NA | NA | NA | NA | NA | NA |
| Gomez-Izquierdo [49] | 2017 | Abdominal surgery | 196 | 128 (65.3) | 64 (50) | 64 (50) | 6 (9) | 8 (12) | 42 (66) | 38 (60) | 16 (25) | 18 (28) |
| Wu [50] | 2017 | Neurological surgery | 111 | 63 (56.8) | 33 (52.4) | 30 (47.6) | 13 (40) | 9 (30) | 20 (60) | 21 (70) | 0 (0.0) | 0 (0.0) |
| Zhao [33] | 2018 | Abdominal surgery | 88 | 88 (100) | 44 (50) | 44 (50) | NA | NA | 31 (70) | 29 (66.6) | 13 (30) | 15 (33.1) |
| Weinberg [29] | 2019 | Abdominal surgery | 61 | 48 (78.7) | 24 (50) | 24 (50) | NA | NA | NA | NA | 18 (75) | 21 (88) |
Pt., patients; N; number of patients; NA, data not available; ASA, American Society of Anesthesiologists physical status; GDT, goal-directed therapy