Table 3.
Summary of perioperative fluids administered in the included studies
| Study | Total intraoperative fluid administration | Total perioperative Fluid administration (95% CI) |
||||||
|---|---|---|---|---|---|---|---|---|
| Colloids (ml) (95% CI/SD) | Crystalloids (ml) (95% CI/SD) | Intraoperative blood (ml) | ||||||
| GDT | Controls | GDT | Controls | GDT | Controls | GDT | Controls | |
| Conway [41] | 1960 (NA) | 1325 (NA) | NA | NA | NA | NA | 4522 (NA) | 3770 (NA) |
| Wakeling [42] | 2000 (NA)* | 1500 (NA) | 3000 (NA) | 3000 (NA) | NA | NA | 5000 (NA) | 4500 (NA) |
| Pearse [30] | 1907 (NA)* | 930 (NA) | 1204 (NA) | 960 (NA) | 125 (0–734) | 0 (0–485) | 2837 (NA) | 2164 |
| Lobo [26] | NA | NA | NA | NA | 713 (458) | 609 (244) | 7447 (NA) | 6877 (NA) |
| Donati [31] | 1940 (673) | 1805 (611) | NA | NA | 260 (130) | 271 (173) | 4131 (NA) | 4014 (NA) |
| Benes [25] | 1425 (1000–1500) | 1000 (540–1250) | 2321 (1640–3002) | 2459 (1529–3389) | 0 (0–500) | 270 (0–578) | 5333 (NA) | 4987 (NA) |
| Mayer [43] | 1188 (638–1738)* | 817 (350–1284) | 2489 (1684–3294) | 3153 (1889–4417)* | NA | NA | 4528 (2211–6845) | 4494 (2933–6055) |
| Brandstrup [32] | 810 (NA)* | 475 (NA) | 483 (NA) | 443 (NA) | 78 (278) | 77 (407) | 6144 (NA) | 5909 (NA) |
| Salzwedel [27] | 773 (109–1437) | 724 (4–1444) | 2862 (1646–4078) | 2680 (1526–3834) | 145 (371) | 224 (1036) | 7053 (NA) | 7597(NA) |
| McKenny [44] | 1000 (1000–1500)* | 500 (0–1000) | 1000 (787–1750) | 2000 (1725–2500)* | NA | NA | 2620 (NA) | 2881 (NA) |
| Scheeren [28] | 1589 (1150–2028) | 927 (631–1223) | NA | NA | 319 (495) | 685 (832) | 4477 (3740–5214) | 4528 (3693–5363) |
| Srinivasa [45] | 591 (471) | 297 (275) | NA | NA | NA | NA | 5744 (NA) | 4014 (NA) |
| Pearse [19] | 1250 (1000–2000) | 500 (0–1000) | 1000 (459–2000) | 2000 (1283–3000) | NA | NA | 3256 (NA) | 3100 (NA) |
| Phan [46] | 500 (250–750)* | 0 (0–300) | 1500 (1000–2000) | 1400 (1000–2000) | NA | NA | 4470 (NA) | 3916 (NA) |
| Ackland [47] | 500 (0–1000) | 625 (0–1438) | 3000 (2000–4000) | 3000 (2000–4000) | NA | NA | 5000 (NA) | 4748 (NA) |
| Correa-Gallego [48] | NA | NA | NA | NA | NA | NA | 3800 (NA) | 4500 (NA) |
| Weinberg [34] | 200 (500–700) | 200 (175–550) | 1875 (1000–2000) | 4000 (2313–4206)* | NA | NA | 4516 (NA) | 7034 (NA) |
| Gomez-Izquierdo [49] | 500 (323–687) | 2102 (1600–2528)* | 900 (400–1400)* | 0 (0–500) | NA | NA | 1819 (NA) | 2914 (NA) |
| Wu [50] | 900 (400–1400)* | 0 (0–500) | 500 (323–687) | 2102 (1600–2528) | NA | NA | 1535 (1000–2272) | 2370 (1779–3071) |
| Zhao [33] | 775 (539–1011)* | 487 (435–539) | 471 (371–571) | 459 (427–491) | 885 (377) | 443 (140) | 1478 (1167–1790) | 1183 (1120–1246) |
| Weinberg yyy[29] | 200 (500–700) | 200 (175–550) | 1875 (1000–2000) | 2000 (1125–2000) | 356 (248–465) | 465 (465–465) | 4950 (NA) | 4450 (NA) |
NA, data not available; GDT, patients’ subgroup receiving goal-directed therapy; ml, milliliters. Data are reported including 95% confidence interval (95%CI) or standard deviation (SD), as appropriate; when NA is present after a value, it implies a computation of available data reported in the paper. Perioperative fluid therapy reports the overall amount of fluid includes the fluid infused during the operation and within the first 24 h in the critically ill area. * = difference reported in the study as statistically significant among GDT/controls subgroups regarding intraoperative colloids or crystalloids administration