Fig. 3.

Regulation of macrophagic polarization by ncRNAs (miRNAs and lncRNAs) reported in different types of cancers. The schematic figure illustrates ncRNAs acting as oncogenes or tumor suppressors that play an important role in macrophagic activation and polarization. The cytokines driving the M1 and M2 polarization are listed. ncRNAs acting as tumor suppressors or oncogenes in driving the M1 and M2 polarization respectively have been shown. The “juggling” oncogenes or tumor suppressors have dual roles as mentioned in the figure. The pro-inflammatory and anti-inflammatory cytokines listed are produced by M1 and M2 macrophages respectively after polarization that further regulate the downstream processes. Red: Inhibit; Green: Promote