Table 2.
Summary of all the ncRNAs that are currently reported to be involved in regulating macrophage polarization in different types of cancer
| ncRNA | Cancer type | Macrophage polarization | Targets/signaling pathways | Categorization | Reference |
|---|---|---|---|---|---|
| miR-34-a | BC | Promote M1 Polarization, Inhibit M2 Polarization | IL-6R, STAT3 | Juggling Tumor Suppressor | [44, 45] |
| miR-16 | BC | Promote M1 Polarization, Inhibit M2 Polarization | IL-6, TGFβ, TNFα | Juggling Tumor Suppressor | [39] |
| miR-503 | BC | Promote M2 Polarization, Inhibit M1 Polarization | STAT3 phosphorylation, NF-kB | Juggling Oncogene | [55] |
| miR-19a-3p | BC | Promote M2 Polarization | Fra-1 proto-oncogene, TNFα, NF-kB | Oncogene | [40, 41] |
| lncRNA GNAS-AS1 | BC, NSCLC | Promote M2 Polarization | p53 | Oncogene | [82, 83] |
| LincRNA p21 | BC | Promote M2 Polarization | miR-1303 sponging, PTBP3 | Oncogene | [101–104] |
| lncRNA BCRT1 | BC | Promote M2 Polarization | miR-433-3p sponging, IL-10 and Arg-1 | Oncogene | [65] |
| miR-Let-7b | PC | Promote M2 Polarization | IL-12, IL-23, TNFα | Oncogene | [58–62] |
| miR-224 | PC | Promote M2 Polarization | TRIB1, IKB-zeta | Oncogene | [52, 53] |
| lncRNA CCAT1 | PC | Promote M1 Polarization, Inhibit M2 Polarization | lncRNA CCAT1/miR-148a/PKCζ axis | Juggling Tumor Suppressor | [66–68] |
| miR-301a-3p | PANC | Promote M2 Polarization | PTEN/PI3Kgamma | Oncogene | [54, 117] |
| miR-155 | PANC, leukemia | Promote M1 Polarization | C/EBPβ | Tumor Suppressor | [48–50] |
| miR-1246 | glioma, OC | Promote M2 Polarization | NF-kB-STAT3-TERF2IP axis | Oncogene | [56] |
| miR-142-3p | glioma | Promote M1 Polarization | TGF-β | Tumor Suppressor | [46, 118] |
| lncRNA LINC00662 | HCC | Promote M2 Polarization | Wnt/β-catenin | Oncogene | [84, 85, 88] |
| lncRNA MALAT1 | HCC | Promote M2 Polarization, Inhibit M1 Polarization | miR-140, VEGF-A | Juggling Oncogene | [92, 93] |
| lncRNA TUC339 | HCC | Promote M2 Polarization | IL-1 β, TNFα | Oncogene | [109, 110] |
| lncRNA COX-2 | HCC | Promote M1 Polarization, Inhibit M2 Polarization | IL-12, iNOS, and TFN-alpha(M1), Arg-1, IL-10, and Fizz-1(M2) | Juggling Tumor Suppressor | [71, 72] |
| miR-145 | CRC | Promote M2 Polarization | IL-12p40, IL-10, HDAC11 | Oncogene | [47] |
| miR-195-5p | CRC | Promote M2 Polarization | miR-195-5p/NOTCH2-GATA3/IL-4 axis | Oncogene | [51] |
| lncRNA GAS5 | CRC | Promote M1 Polarization, Inhibit M2 Polarization | IRF4 | Juggling Tumor Suppressor | [75, 76] |
| lncRNA RPPH1 | CRC | Promote M2 Polarization | TUBB3 | Oncogene | [105–107] |
| lncRNA MM2P | OS | Promote M2 Polarization | STAT6 | Oncogene | [94] |
| lncRNA RP11-361F15.2 | OS | Inhibit M2 Polarization | miR-30c-5p, CPEB4 | Tumor Suppressor | [108] |
| miR-29a-3p | OSCC | Promote M2 Polarization | SOCS1/STAT6 signaling | Oncogene | [43] |
| miR-21 | HNC | Promote M2 Polarization | PDCD4, IL12A | Oncogene | [42] |
| lncRNA NIFK-AS1N | EC | Promote M1 Polarization, Inhibit M2 Polarization | NIFK-AS1/miR-146a/NOTCH1 axis | Juggling Tumor Suppressor | [99] |
| lncRNA ANCR | GC | Inhibit M1 Polarization | FOXO1 | Oncogene | [63] |
| lncRNA NEAT1 | MM | Promote M2 Polarization | lncRNA NEAT1/miR-214/B7-H3/JAK2-STAT3 axis | Oncogene | [95, 96] |
| lncRNA XIST | LC | Promote M2 Polarization | IL-4, TCF-4 | Oncogene | [111, 114] |