Table 3.

Multivariate logistic regression analysis for risk factors of diarrhea in patients receiving naldemedine

Variables	Odds ratio	95% CI	P value
Female	3.012	0.887–10.228	0.077
Performance status (3–4)	2.806	0.567–13.887	0.206
Opioid dose (morphine base, mg)	1.001	0.987–1.016	0.853
Naldemedine administration after more than 17 days of opioid therapy	7.539	1.446–39.305	0.016
PPI or H2-blocker	2.323	0.476–11.334	0.297
Fentanyl	0.552	0.082–3.720	0.541
Pancreatic cancer	6.217	1.257–30.378	0.025

CI Confidence interval, PPI Proton-pump inhibitor