TABLE 2.

Univariable and multivariable analysis of risk and protective factors for cognitive and motor changes during quarantine in patients with dementia.

	Univariable analysis		Multivariable analysis
	Crude OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value	P-value after Bonferroni correction
Changes in cognitive symptoms
Age	1.00 (0.99 – 1.00)	0.24
Sex (men vs. women)	1.15 (1.01 – 1.30)	0.03	1.13 (0.99 – 1.29)	0.07	1
Duration of the disease (years)	0.95 (0.93 – 0.97)	<0.001	0.94 (0.92 – 0.97)	<0.001	<0.001
Duration of quarantine (days)	1.00 (0.99 – 1.01)	0.97
Disease severity – CDR 2	1.29 (1.11 – 1.50)	<0.001	1.19 (1.00 – 1.42)	0.05	1
Disease severity – CDR 3	1.02 (0.86 – 1.21)	0.81	0.93 (0.74 – 1.17)	0.52	1
Total physical independence	1.74 (1.40 – 2.16)	<0.001	1.85 (1.42 – 2.39)	<0.001	<0.001
Partial physical independence	2.19 (1.80 – 2.67)	<0.001	2.08 (1.68 – 2.57)	<0.001	<0.001
Total awareness of pandemic	0.74 (0.65 – 0.85)	<0.001	0.68 (0.57 – 0.81)	<0.001	<0.001
Partial awareness of pandemic	1.39 (1.18 – 1.64)	<0.001	1.20 (1.00 – 1.43)	0.05	1
Changes in motor symptoms
Age	1.03 (1.02 – 1.04)	<0.001	1.02 (1.01 – 1.03)	<0.001	0.001
Sex (men vs. women)	1.11 (0.98 – 1.25)	0.12
Duration of the disease (years)	1.05 (1.03 – 1.07)	<0.001	1.00 (0.98 – 1.03)	0.86	1
Duration of quarantine (days)	1.00 (0.99 – 1.01)	0.99
Disease severity – CDR 2	1.94 (1.65 – 2.29)	<0.001	1.29 (1.07 – 1.56)	0.009	0.29
Disease severity – CDR 3	3.08 (2.56 – 3.70)	<0.001	1.60 (1.26 – 2.02)	<0.001	0.004
Total physical independence	0.32 (0.25 – 0.40)	<0.001	0.49 (0.37 – 0.64)	<0.001	<0.001
Partial physical independence	0.93 (0.77 – 1.12)	0.44	1.06 (0.86 – 1.30)	0.59	1
Total awareness of pandemic	0.44 (0.38 – 0.51)	<0.001	0.76 (0.64 – 0.91)	0.003	0.10
Partial awareness of pandemic	0.75 (0.64 – 0.88)	<0.001	0.93 (0.78 – 1.10)	0.39	1

OR, Odds ratio; 95% CI, 95% confidence interval; CDR, Clinical Dementia Rating.