TABLE 3.

Univariable and multivariable analysis of risk and protective factors for increase in BPSD and onset of new BPSD during quarantine in patients with dementia.

	Univariable analysis		Multivariable analysis
	Crude OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value	P-value after Bonferroni correction
Increase in BPSD
Age	0.99 (0.98 – 0.99)	<0.001	0.99 (0.98 – 0.99)	0.005	0.16
Sex (men vs. women)	1.17 (1.04 – 1.32)	0.008	1.12 (0.99 – 1.28)	0.08	1
Duration of the disease (years)	0.98 (0.96 – 0.99)	0.04	0.97 (0.95 – 0.99)	0.01	0.48
Duration of quarantine (days)	0.99 (0.99 – 1.01)	0.66
Disease severity – CDR 2	1.33 (1.15 – 1.54)	<0.001	1.26 (1.06 – 1.49)	0.009	0.30
Disease severity – CDR 3	1.32 (1.12 – 1.56)	0.001	1.21 (0.97 – 1.52)	0.09	1
Total physical independence	1.56 (1.26 – 1.93)	<0.001	1.84 (1.43 – 2.38)	<0.001	<0.001
Partial physical independence	1.90 (1.57 – 2.30)	<0.001	1.88 (1.53 – 2.31)	<0.001	<0.001
Total awareness of pandemic	0.72 (0.63 – 0.82)	<0.001	0.75 (0.63 – 0.89)	<0.001	0.03
Partial awareness of pandemic	1.25 (1.07 – 1.45)	0.005	1.20 (1.01 – 1.42)	0.04	1
Onset of new BPSD
Age	1.00 (0.99 – 1.00)	0.32
Sex (men vs. women)	1.19 (1.04 – 1.36)	0.01	1.10 (0.95 – 1.27)	0.21	1
Duration of the disease (years)	0.99 (0.97 – 1.01)	0.41
Duration of quarantine (days)	1.00 (0.99 – 1.01)	0.72
Disease severity – CDR 2	1.14 (0.96 – 1.35)	0.13
Disease severity – CDR 3	1.08 (0.89 – 1.32)	0.41
Total physical independence	1.69 (1.30 – 2.18)	<0.001	1.92 (1.45 – 2.55)	<0.001	<0.001
Partial physical independence	1.59 (1.26 – 2.02)	<0.001	1.55 (1.22 – 1.99)	<0.001	0.01
Total awareness of pandemic	0.78 (0.67 – 0.92)	0.003	0.74 (0.62 – 0.88)	<0.001	0.03
Partial awareness of pandemic	1.17 (0.99 – 1.39)	0.07	1.10 (0.92 – 1.32)	0.29	1

BPSD, Behavioral and Psychological Symptoms of Dementia; OR, Odds ratio; 95% CI, 95% confidence interval; CDR, Clinical Dementia Rating.