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. 2020 Dec 11;40(3):e105643. doi: 10.15252/embj.2020105643

Figure EV2. Fitting of molecular models into the cryo‐EM maps of ss‐bound and apo Sec complex.

Figure EV2

  • A
    View focusing on the lateral gate of Sec61α. In the ss‐bound state (left), the signal sequence of ppαF (red) is inserted into the lateral gate (TM2 and TM7) and the two Sec62 TM helices are stabilized. In the apo state (right), density for the plug (P) is present below the central pore.
  • B
    View focusing on the N‐terminal half of Sec61α (TMs 2, 3 and 4). In the ss‐bound state (left), Sec62 TM1 is bound near Sec61α TM2.
  • C
    View focusing on the C‐terminal half of Sec61α (TMs 6‐9).
  • D
    View focusing on the cytosolic domains of the Sec complex.