TABLE III. TB-profiler versus MTBSEQ whole-genome sequencing tools according to Kappa Coefficient.

	Kappa (Interpretation)		Observed concordance		Replicability		95% CI		p-value
Drugs	TB-profiler	MTBSEQ	TB-profiler	MTBSEQ	TB-profiler	MTBSEQ	TB-profiler	MTBSEQ	TB-profiler	MTBSEQ
INH	0.854	0.692	92.96%	84.51%	Almost perfect	Substantial	0.731 to 0.977	0.528 to 0.856	<0.0001	<0.0001
RIF	0.792	0.713	91.55%	88.73%	Substantial	Substantial	0.635 to 0.949	0.528 to 0.898	<0.0001	<0.0001
PZA	0.508	0.238	92.96%	87.32%	Moderate	Fair	0.133 to 0.882	-0.108 to 0.585	<0.0001	<0,0219
EMB	0.645	0.653	90.41%	91.55%	Substantial	Substantial	0.411 to 0.879	0.400 to 0.906	<0.0001	<0.0001
SM	0.776	0.718	95.77%	94.73%	Substantial	Substantial	0.533 to 1.000	0.457 to 0.980	<0.0001	<0.0001

INH: isoniazid; RIF: rifampicin; PZA: pyrazinamide; EMB: ethambutol; SM: streptomycin; 95% CI: 95% confidence interval.