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The mechanistic target of rapamycin (mTOR) signaling pathway controls metabolism and cell survival. mTORC1 stimulates multiple anabolic metabolic pathways (lipid and protein synthesis) in the presence of nutrients and growth factors. Conversely, limiting nutrient or growth factor availability promotes catabolic pathways (autophagy). mTORC2 promotes cell survival through activation of AKT. (Adapted from Laplante and Sabatini 2012.)
