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Synergy between chromatin remodeling and pluripotency factor binding. Four hallmarks of pluripotent stem cells are represented by the colored gears. The binding of pluripotency factors (e.g., SOX2, NANOG, OCT4) can bring about the recruitment of chromatin remodeling complexes (e.g., esBAF, CHD1, p300). This leads to histone exchange as nucleosomes are disassembled, which in turn promotes accessible regions of DNA and permits further binding of transcription factors.
