FIG 6.

Regulation of chemosensory signaling by c-di-GMP. (A) 3D structures of CheR₁/MapZ complex (PDB ID 5Y4R) (174), the WspR response regulator (3BRE) (105), and the transcriptional regulator FleQ (5EXX) (180) in complex with c-di-GMP, representing three different mechanisms by which c-di-GMP modulates pathway signaling. (B) Schematic view of chemosensory pathway-associated signaling by c-di-GMP. The Wsp and Chp pathways are involved in the synthesis of c-di-GMP that, in turn, reduces chemotaxis through the action of the FleQ and MapZ regulatory proteins.